1-(3-甲基-1,2,4-恶二唑-5-基)丙酮合成路线 (共 3 条)
反应条件
triethylamine in 1,4-dioxane
15 h; Heating;
参考文献
Boehme, Thomas M.; Augelli-Szafran, Corinne E.; Hallak, Hussein; Pugsley, Thomas; Serpa, Kevin; Schwarz, Roy D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3094 - 3102
反应条件
T=95 - 100°C; Neat (no solvent);
参考文献
Huang, Tong-Hui; Tu, Hai-Yang; Liu, Ming; Zhang, Ai-Dong
Heterocycles, 2011 , vol. 83, # 1 p. 91 - 97
反应条件
1.) CH3OH, 2 h, 0 deg C, 2.) CH3OH, toluene, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Kuebel, Boerries
Monatshefte fuer Chemie, 1982 , vol. 113, p. 781 - 792