1: With triethylamine in methanol T=8 - 12°C; 2: With sulfuric acid in methanol; water T=0 - 20°C; pH=2.4 - 2.5; Product distribution / selectivity;

1: methanesulfonic acid / 5 - 12 °C 2: triethylamine / water; methanol / 15 - 20 °C View Scheme

water in N,N-dimethyl-formamide T=37°C; phosphate buffer, var. pH, add of bovin serum albumin (as protein); Rate constant;

disodium hydrogenphosphate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene in isobutyramide T=-10 - -5°C; 2.16667 h;

1: Cefpodoxime With N,N,N',N'-tetramethylguanidine in isobutyramide T=-12 - -4°C; 1 h; 2: 1-(isopropyloxycarbonyloxy)ethyl iodide in isobutyramide T=-15 - -8°C; 0.5 - 1.5 h; Product distribution / selectivity;