1: 2-bromo-5-fluoropyridine With n-butyllithium in hexanes; toluene T=-78°C; 1.5 h; 2: N,N-dimethyl-formamide in hexanes; toluene T=-78°C; 2 h; 3: With sodium tetrahydroborate; water; sodium hydrogencarbonate more than 3 stages;

lithium borohydride in tetrahydrofuran T=0 - 20°C; 1 h;

sodium tetrahydroborate in tetrahydrofuran; hexane; toluene T=0 - 20°C; 1 h;