N-(1,2,3,4-四氢-8-甲氧基-2-萘基)乙酰胺合成路线 （共 4 条）
反应条件
hydrogenchloride; sodium hydroxide; borane in tetrahydrofuran; ethanol; dichloromethane
参考文献
SmithKline Corporation
Patent: US4320148 A1, 1982 ;
反应条件
sodium acetate in water; ethyl acetate
3 h;
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
反应条件
triethylamine in dichloromethane
1 h; Ambient temperature;
参考文献
Mathe-Allainmat, Monique; Gaudy, Florence; Sicsic, Sames; Dangy-Caye, Anne-Laure; Shen, Shuren; Bremont, Beatrice; Benatalah, Zohra; Langlois, Michel; Renard, Pierre; Delagrange, Philippe
Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3089 - 3095
反应条件
1: 1 N NaOH / ethanol; H2O / pH 8.2
2: 1.) B2H6, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) reflux, 15 min
3: 2.5 N NaOH / CH2Cl2
View Scheme
参考文献
DeMarinis, R. M.; Shah, D. H.; Hall, R. F.; Hieble, J. P.; Pendleton, R. G.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 136 - 141
