3-(3,4-二氯苯基)-3-苯丙酸合成路线 （共 8 条）
反应条件
sulfuric acid in ethyl acetate; benzene
参考文献
Pharm-Eco Laboratories, Inc.
Patent: US6268535 B1, 2001 ;
反应条件
AlCl3, aluminium chloride
T=20°C; 23 h;
参考文献
Grimm, Stefanie H.; Allmendinger, Lars; Hoefner, Georg; Wanner, Klaus T.
Chirality, 2013 , vol. 25, # 12 p. 923 - 933
反应条件
potassium hydroxide in ethanol; water
3 h; Reflux;
参考文献
Pastre, Julio Cezar; Correia, Carlos Roque Duarte
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 9 p. 1217 - 1223
反应条件
1: piperidine / toluene / 0.5 h / Heating
2: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
3: aq. H2SO4, CH3COOH / 24 h / Heating
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
sulfuric acid; acetic acid
24 h; Heating; Yield given;
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
2: aq. H2SO4, CH3COOH / 24 h / Heating
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
2: aq. H2SO4, CH3COOH / 24 h / Heating
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 91 percent / polyphosphoric acid (PPA) / 2 h / 100 °C
2: 76 percent / sodium borohydride / methanol / 1 h / Ambient temperature
3: SOCl2 / toluene / 1.) RT, 30 min, 2.) from 50 deg C to 55 deg C, 1 h
4: butan-2-one / 16 h / Heating
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
