3-(4-氟苯基)-6-甲基茚满-1-酮合成路线 （共 4 条）
反应条件
PPA; Polyphosphoric acid (PPA)
T=95°C; 3 h;
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
2: aq. H2SO4, CH3COOH / 24 h / Heating
3: 62 percent / polyphosphoric acid (PPA) / 3 h / 95 °C
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: aq. H2SO4, CH3COOH / 24 h / Heating
2: 62 percent / polyphosphoric acid (PPA) / 3 h / 95 °C
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
2: aq. H2SO4, CH3COOH / 24 h / Heating
3: 62 percent / polyphosphoric acid (PPA) / 3 h / 95 °C
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
