3-(4-氟苯基)-6-(三氟甲基)茚满-1-酮合成路线 （共 8 条）
反应条件
n-butyllithium in diethyl ether; hexane
T=0°C; 0.5 h;
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 82 percent / piperidine / toluene / 0.5 h / Heating
2: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
3: aq. H2SO4, CH3COOH / 24 h / Heating
4: 82 percent / n-butyllithium / hexane; diethyl ether / 0.5 h / 0 °C
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
2: aq. H2SO4, CH3COOH / 24 h / Heating
3: 82 percent / n-butyllithium / hexane; diethyl ether / 0.5 h / 0 °C
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: aq. H2SO4, CH3COOH / 24 h / Heating
2: 82 percent / n-butyllithium / hexane; diethyl ether / 0.5 h / 0 °C
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
1: 1.) t-BuOK / 1.) DMF, 20-25 deg C, 1 h; 2.) 17 h
2: 1.) acetic acid, 2.) 60 percent aq. H2SO4 / 1.) 100 deg C, 2.) 110 deg C, 6 h
3: N-methylpyrrolidone / 1 h / 100 °C
View Scheme
参考文献
Sommer, Michael Bech; Begtrup, Mikael; Boegesoe, Klaus Peter
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4822 - 4827
反应条件
1: 1.) t-BuOK / 1.) DMF, 20-25 deg C, 1 h; 2.) 17 h
2: 1.) acetic acid, 2.) 60 percent aq. H2SO4 / 1.) 100 deg C, 2.) 110 deg C, 6 h
3: N-methylpyrrolidone / 1 h / 100 °C
View Scheme
参考文献
Sommer, Michael Bech; Begtrup, Mikael; Boegesoe, Klaus Peter
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4822 - 4827
反应条件
1: 1.) acetic acid, 2.) 60 percent aq. H2SO4 / 1.) 100 deg C, 2.) 110 deg C, 6 h
2: N-methylpyrrolidone / 1 h / 100 °C
View Scheme
参考文献
Sommer, Michael Bech; Begtrup, Mikael; Boegesoe, Klaus Peter
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4822 - 4827
反应条件
1: 75 percent / sodium borohydride / methanol / 1 h / Ambient temperature
2: 100 percent / SOCl2 / toluene / 1.) RT, 30 min, 2.) from 50 deg C to 55 deg C, 1 h
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
