N-(2-羟基苄基)乙酰胺合成路线 （共 12 条）
反应条件
boron tribromide in dichloromethane
T=-10 - 20°C; 2 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; GOODNOW JR., Robert Alan; HAMILTON, Matthew Michael; KOWALCZYK, Agnieszka; SIDDURI, Achyutharao
Patent: WO2013/110578 A1, 2013 ;
Location in patent: Page/Page column 45; 46 ;
反应条件
1: in methanol
T=20°C; 2 h;
2: With boron tribromide in dichloromethane
T=0°C;
参考文献
ASTRAZENECA AB?
Patent: WO2005/49620 A1, 2005 ;
Location in patent: Page/Page column 31-32 ;
WO 2005/049620 A1
参考文献
Gabriel
Justus Liebigs Annalen der Chemie, 1915 , vol. 409, p. 319
反应条件
1: sodium acetate
2: alcoholic KOH-solution
View Scheme
参考文献
Raiford; Clark
Journal of the American Chemical Society, 1923 , vol. 45, p. 1740
反应条件
1: sodium amalgam; alcohol
2: sodium acetate
3: alcoholic KOH-solution
View Scheme
参考文献
Raiford; Clark
Journal of the American Chemical Society, 1923 , vol. 45, p. 1740
反应条件
1: hydroxylamine
2: sodium amalgam; alcohol
3: sodium acetate
4: alcoholic KOH-solution
View Scheme
参考文献
Raiford; Clark
Journal of the American Chemical Society, 1923 , vol. 45, p. 1740
反应条件
KNO2; sulfuric acid
T=50°C;
参考文献
Gabriel
Justus Liebigs Annalen der Chemie, 1915 , vol. 409, p. 319
反应条件
1: acetic anhydride / 20 °C
2: boron tribromide / dichloromethane / 2 h / -10 - 20 °C / |Inert atmosphere
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; GOODNOW JR., Robert Alan; HAMILTON, Matthew Michael; KOWALCZYK, Agnieszka; SIDDURI, Achyutharao
Patent: WO2013/110578 A1, 2013 ;
反应条件
potassium superoxide; 18-crown-6 ether in benzene
168 h; Ambient temperaturearomatic ortho and para hydroxylation of various N-benzylamides with potassium superoxide; MechanismProduct distribution;
参考文献
Galliani, Guido; Rindone, Bruno
Tetrahedron, 1981 , vol. 37, p. 2313 - 2318
参考文献
Sekiya,M. et al.
Chemical and Pharmaceutical Bulletin, 1961 , vol. 9, # 12 p. 945 - 948
