3-碘-1-(苯磺酰)吲哚合成路线 （共 24 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); ethylmagnesium bromide in tetrahydrofuran 1.) 0 deg C, 30 min, r.t., 30 min; 2.) r.t., overnight;
参考文献
Kondo, Yoshinori; Yoshida, Akihiro; Sato, Shuichiroh; Sakamoto, Takao
Heterocycles, 1996 , vol. 42, # 1 p. 105 - 108
反应条件
1: 3-iodo-1-(phenylsulfonyl)-1H-indole With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-60°C; 0.166667 h; 2: C8H8O5 in tetrahydrofuran; n-heptane; ethylbenzene T=-60 - 20°C; 1 h;
参考文献
Abbiati; Beccalli; Marchesini; Rossi
Synthesis, 2001 , # 16 p. 2477 - 2483
反应条件
1: 3-iodo-1-(phenylsulfonyl)-1H-indole With i -Pr2Zn; Li(acac) in 1-methyl-pyrrolidin-2-one T=20°C; 12 h; 2: allyl bromide in tetrahydrofuran T=20°C;
参考文献
Gong, Liu-Zhu; Knochel, Paul
Synlett, 2005 , # 2 art. no. G41404ST, p. 267 - 270
反应条件
piperidine; biphenyl-2-yl-di-tert-butyl-phosphane; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene T=100°C;
参考文献
Sergeev; Artamkina; Velezheva; Fedorova; Beletskaya
Russian Journal of Organic Chemistry, 2005 , vol. 41, # 6 p. 860 - 874
参考文献
Moriarty, Robert M.; Ku, Y. Y.; Sultana, M.; Tuncay, Atilla
Tetrahedron Letters, 1987 , vol. 28, # 27 p. 3071 - 3074
反应条件
triethylamine; palladium diacetate T=120°C; P=4560 Torr; 24 h;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Takazawa, Nobuo; Yamanaka, Hiroshi
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 16 p. 1927 - 1934
反应条件
ethylmagnesium bromide in tetrahydrofuran 1.) 0 deg C, 30 min, r.t., 30 min; 2.) r.t., overnight;
参考文献
Kondo, Yoshinori; Yoshida, Akihiro; Sato, Shuichiroh; Sakamoto, Takao
Heterocycles, 1996 , vol. 42, # 1 p. 105 - 108
反应条件
1: 50 percent
2: 2N NaOH / methanol / 4 h
View Scheme
参考文献
Moriarty, Robert M.; Ku, Y. Y.; Sultana, M.; Tuncay, Atilla
Tetrahedron Letters, 1987 , vol. 28, # 27 p. 3071 - 3074
反应条件
1: tert-butyllithium / tetrahydrofuran; pentane / 0.08 h / -100 °C
2: tetrahydrofuran / 6 h / -100 - 20 °C
View Scheme
参考文献
Saulnier, Mark G.; Gribble, Gordon W.
Journal of Organic Chemistry, 1982 , vol. 47, # 5 p. 757 - 761
反应条件
iodine; lithium diisopropyl amide
Substitution;
参考文献
Liu; Gribble
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8717 - 8721
