1-(苯磺酰)-1H-吲哚-2-甲醛合成路线 （共 14 条）
反应条件
1: 99 percent / benzene / 1.) 0 deg C, 30 min 2.) room temperature 3.) 19 h reflux
2: 84 percent / p-TsOH / benzene / 1 h / Heating
3: 86 percent / K2CO3 / ethanol / 15 h / Heating
4: 1.) potassium tert-butoxide 2.) 4N hydrochloric acid / 1.) Et2O, 0 deg C, 30 min 2.) methanol, 3 h reflux
View Scheme
参考文献
Rubiralta, Mario; Diez, Anna; Vila, Cristina
Tetrahedron, 1990 , vol. 46, # 12 p. 4443 - 4456
反应条件
diisobutylaluminium hydride in tetrahydrofuran; hexane
T=-78°C; 1 h;
参考文献
De Dios, Alfonso; Prieto, Lourdes; Martin, Jose Alfredo; Rubio, Almudena; Ezquerra, Jesus; Tebbe, Mark; Lopez De Uralde, Beatriz; Martin, Justina; Sanchez, Ana; LeTourneau, Deborah L.; McGee, James E.; Boylan, Carole; Parr Jr., Thomas R.; Smith, Michele C.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4559 - 4570
反应条件
1: acetic acid / 20 - 80 °C
2: potassium tert-butylate / tert-butyl alcohol / 6 h / |Reflux
View Scheme
参考文献
Naik, Nilesh H.; Urmode, Tukaram D.; Sikder, Arun K.; Kusurkar, Radhika S.
Australian Journal of Chemistry, 2013 , vol. 66, # 9 p. 1112 - 1114
反应条件
1: 99 percent / benzene / 1.) 0 deg C, 30 min 2.) room temperature 3.) 19 h reflux
2: 84 percent / p-TsOH / benzene / 1 h / Heating
3: 86 percent / K2CO3 / ethanol / 15 h / Heating
4: 1.) potassium tert-butoxide 2.) 4N hydrochloric acid / 1.) Et2O, 0 deg C, 30 min 2.) methanol, 3 h reflux
View Scheme
参考文献
Rubiralta, Mario; Diez, Anna; Vila, Cristina
Tetrahedron, 1990 , vol. 46, # 12 p. 4443 - 4456
