2-(2-氧代丁基)异吲哚啉-1,3-二酮合成路线 （共 10 条）
反应条件
piperidine; acetic acid 1.) 20 deg C, 145 h, 2.) 20 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Zav'yalov, S. I.; Zavozin, A. G.; Kravchenko, N. E.; Ezhova, G. I.; Sitkareva, I. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 12 p. 2524 - 2527
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 12 p. 2756 - 2759
反应条件
hydrogenchloride in acetic acid Heating;
参考文献
Adam, Isabelle; Orain, David; Meier, Peter
Synlett, 2004 , # 11 p. 2031 - 2033
反应条件
in N,N-dimethyl-formamide
Heating;
参考文献
Brown, Pamela; Davies, David T.; O'Hanlon, Peter J.; Wilson, Jennifer M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 446 - 457
反应条件
sodium metaborate; tetra-(n-butyl)ammonium iodide; potassium bromide in N,N-dimethyl-formamide
T=20°C; 10 h;
参考文献
Zav'yalov, S. I.; Ezhova, G. I.; Sitkareva, I. V.; Zavozin, A. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, p. 1739
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 8 p. 1940
参考文献
Kolshorn
Chemische Berichte, 1904 , vol. 37, p. 2481
反应条件
pyridinium chlorochromate in dichloromethane
2.5 h;
参考文献
Chapman Jr.; Cocolas; Hall
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 11 p. 1344 - 1347
反应条件
1: 41 percent / toluene / 2 h / Heating
2: 14 percent / PCC / CH2Cl2 / 2.5 h
View Scheme
参考文献
Chapman Jr.; Cocolas; Hall
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 11 p. 1344 - 1347
反应条件
bromine; urea
1.) DMF, 1 h, 2.) DMF, 20 deg C, 0.5 h; Yield given. Multistep reaction;
参考文献
Zav'yalov, S. I.; Zavozin, A. G.; Kravchenko, N. E.; Ezhova, G. I.; Sitkareva, I. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 12 p. 2524 - 2527
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 12 p. 2756 - 2759
参考文献
Brown, Pamela; Davies, David T.; O'Hanlon, Peter J.; Wilson, Jennifer M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 446 - 457
参考文献
Kolshorn
Chemische Berichte, 1904 , vol. 37, p. 2481
