3,4-二(2-甲氧基乙氧基)苯甲醛合成路线 （共 9 条）
反应条件
1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2: acetic anhydride / 110 °C 3: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C 5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Jin, Jian-Wen; Zhang, Lin; Meng, Guang-Rong; Zhu, Jian-Hua; Zhang, Qian
Synthetic Communications, 2014 , vol. 44, # 3 p. 346 - 351
反应条件
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C 5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating 6.1: 80 percent / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
反应条件
potassium carbonate in N,N-dimethyl-formamide
Heating;
参考文献
Li, Ren-li; Hansch, Corwin; Kaufman, Bernard T.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 435 - 440
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C;
参考文献
VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION
Patent: WO2007/138613 A2, 2007 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium carbonate in acetone
T=25 - 30°C; 6 h; RefluxHeating;
参考文献
Natco Pharma Limited
Patent: US2010/298351 A1, 2010 ;
Location in patent: Page/Page column 35 ;
US 20100298351 A1
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetone
4 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2007/71348 A1, 2007 ;
Location in patent: Page/Page column 83-84 ;
反应条件
1: hydroxylamine hydrochloride; pyridine / methanol / Heating
2: acetic anhydride / 110 °C
View Scheme
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
