3-(1H-吲哚-3-磺酰基)-丙酸合成路线 （共 8 条）
反应条件
1: indole With iodine; thiourea; potassium iodide in methanol; water
T=2°C;
2: β-bromopropionic acid With sodium hydroxide in methanol; water
pH=9;
参考文献
Levkovskaya; Rudyakova; Mirskova
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 11 p. 1641 - 1646
反应条件
potassium hydroxide in ethanol
3 h; Heating;
参考文献
Levkovskaya; Rudyakova; Mirskova
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 11 p. 1641 - 1646
反应条件
sodium hydroxide in ethanol
0.5 h; Ambient temperature; Yield given;
参考文献
Hamel, Pierre; Girard, Mario
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1695 - 1701
反应条件
1: 1.) thiourea, potassium triiodide, 2.) 10 N aq. NaOH
2: 5 N aq. NaOH / ethanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Hamel, Pierre; Girard, Mario
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1695 - 1701
反应条件
1: 8 g / 10percent aq. NaOH / 0.5 h / 80 °C
2: 4.7 g / Triethyl amine / 8 h / Heating
View Scheme
参考文献
Nagarajan, K.; Arya, V. P.; Parthasarathy, T. N.; Shenoy, S. J.; Shah, R. K.; Kulkarni, Y. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 8 p. 672 - 679
反应条件
triethylamine
8 h; Heating;
参考文献
Nagarajan, K.; Arya, V. P.; Parthasarathy, T. N.; Shenoy, S. J.; Shah, R. K.; Kulkarni, Y. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 8 p. 672 - 679
反应条件
PPA
T=115°C; 0.25 h;
参考文献
Hamel, Pierre; Girard, Yves; Atkinson, Joseph G.
Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2694 - 2699
反应条件
polyphosphate ester in chloroform
1 h; Ambient temperature;
参考文献
Hamel, Pierre; Girard, Yves; Atkinson, Joseph G.
Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2694 - 2699
