1: 30 percent / benzene / 16 h / 80 °C 2: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C 3: 40 percent / 1) CBr4; / 2) CH3CN 4: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 5: -78 - -45 °C 6: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 7: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 40 percent / 1) CBr4; / 2) CH3CN 2: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 3: -78 - -45 °C 4: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 5: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C 2: 40 percent / 1) CBr4; / 2) CH3CN 3: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 4: -78 - -45 °C 5: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 6: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

2: TFA / tetrahydrofuran; H2O / 6 h / Ambient temperature 3: Pb(OAc)4, Na2CO3 4: 30 percent / benzene / 16 h / 80 °C 5: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C 6: 40 percent / 1) CBr4; / 2) CH3CN 7: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 8: -78 - -45 °C 9: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 10: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: TFA / tetrahydrofuran; H2O / 6 h / Ambient temperature 2: Pb(OAc)4, Na2CO3 3: 30 percent / benzene / 16 h / 80 °C 4: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C 5: 40 percent / 1) CBr4; / 2) CH3CN 6: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 7: -78 - -45 °C 8: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 9: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 2: -78 - -45 °C 3: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 4: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C 2: 70 percent / LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme