2,2-二氟-1-(2-吡啶基)-乙酮合成路线 （共 2 条）
反应条件
1: 2-bromo-pyridine With n-butyllithium in diethyl ether; hexane
T=-70 - -45°C; Inert atmosphere;
2: CHF2COOEt in diethyl ether; hexane
T=-70 - 20°C; Inert atmosphere;
3: in acetonitrile
Molecular sieve;
参考文献
You, Lei; Anslyn, Eric V.
Organic Letters, 2009 , vol. 11, # 22 p. 5126 - 5129
反应条件
1: 2-bromo-pyridine With n-butyllithium in diethyl ether; hexane
T=-70 - -45°C; Inert atmosphere;
2: CHF2COOEt in diethyl ether; hexane
T=-70 - 20°C; Inert atmosphere;
3: With sulfuric acid; water in diethyl ether; hexane
参考文献
You, Lei; Anslyn, Eric V.
Organic Letters, 2009 , vol. 11, # 22 p. 5126 - 5129
