反应条件
1: 89 percent / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 1.25 h 2: 73 percent / aq. Na2CO3 / PdCl2(PPh3)2 / ethanol; 1,2-dimethoxy-ethane / 4.5 h / 90 °C 3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; H2O / 16 h View Scheme
参考文献
Bruncko, Milan; Oost, Thorsten K.; Belli, Barbara A.; Ding, Hong; Joseph, Mary K.; Kunzer, Aaron; Martineau, Darlene; McClellan, William J.; Mitten, Michael; Ng, Shi-Chung; Nimmer, Paul M.; Oltersdorf, Tilman; Park, Cheol-Min; Petros, Andrew M.; Shoemaker, Alexander R.; Song, Xiaohong; Wang, Xilu; Wendt, Michael D.; Zhang, Haichao; Fesik, Stephen W.; Rosenberg, Saul H.; Elmore, Steven W.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 641 - 662