三异丙基甲硅烷基三氟甲烷磺酸盐合成路线 （共 52 条）
反应条件
1: nona-4,8-diynyl-benzene With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C;
2: With tBuOOLi in tetrahydrofuran; toluene
T=-78 - 0°C; 2.5 h;
3: tri-isopropylsylil trifluoromethane sulfonate in tetrahydrofuran; toluene
T=-78 - 0°C;
参考文献
Zhang, Liming; Sun, Jianwei; Kozmin, Sergey A.
Tetrahedron, 2006 , vol. 62, # 49 p. 11371 - 11380
反应条件
1: octa-3,7-diynyl-benzene With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C;
2: With tBuOOLi in tetrahydrofuran; toluene
T=-78 - 0°C; 2.5 h;
3: tri-isopropylsylil trifluoromethane sulfonate in tetrahydrofuran; toluene
T=-78 - 0°C;
参考文献
Zhang, Liming; Sun, Jianwei; Kozmin, Sergey A.
Tetrahedron, 2006 , vol. 62, # 49 p. 11371 - 11380
反应条件
1: 1,1-dibromo-3,3-dimethyl-dec-5-yn-2-one With lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
3: tri-isopropylsylil trifluoromethane sulfonate in tetrahydrofuran; hexane
T=-78 - 0°C;
参考文献
Sun, Jianwei; Kozmin, Sergey A.
Journal of the American Chemical Society, 2005 , vol. 127, # 39 p. 13512 - 13513
反应条件
1: 3,3-dimethyl-deca-1,5-diyne With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C;
2: With tBuOOLi in tetrahydrofuran; toluene
T=-78 - 0°C; 2.5 h;
3: tri-isopropylsylil trifluoromethane sulfonate in tetrahydrofuran; toluene
T=-78 - 0°C;
参考文献
Zhang, Liming; Sun, Jianwei; Kozmin, Sergey A.
Tetrahedron, 2006 , vol. 62, # 49 p. 11371 - 11380
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: tert.-butyl lithium / hexane; diethyl ether / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C
View Scheme
参考文献
VIAMET PHARMACEUTICALS, INC.; HOEKSTRA, William, J.; SCHOTZINGER, Robert, J.; RAFFERTY, Stephen, William
Patent: WO2012/64943 A2, 2012 ;
反应条件
1: [(2,5-dibromobenzene-1,4-diyl)diethyne-2,1-diyl]-bis(trimethylsilane) With n-butyllithium in diethyl ether; hexane
T=-78°C; 1 h;
2: tri-isopropylsylil trifluoromethane sulfonate in diethyl ether; hexane
T=-78 - 20°C;
参考文献
Zhao, Cui-Hua; Wakamiya, Atsushi; Inukai, Yuko; Yamaguchi, Shigehiro
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15934 - 15935
反应条件
1.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C
1.2: 11 percent / diethyl ether; hexane / -78 - 20 °C
2.1: 85 percent / K2CO3; MeOH / tetrahydrofuran / 5 h / 20 °C
View Scheme
参考文献
Zhao, Cui-Hua; Wakamiya, Atsushi; Inukai, Yuko; Yamaguchi, Shigehiro
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15934 - 15935
反应条件
2,6-dimethylpyridine in dichloromethane
T=-78 - -30°C; 3 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/15588 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
WO 2007/015588 A1
反应条件
2,6-dimethylpyridine in dichloromethane
T=20°C; 4 h;
参考文献
Petri, Andreas F.; Schneekloth Jr., John S.; Mandal, Amit K.; Crews, Craig M.
Organic Letters, 2007 , vol. 9, # 16 p. 3001 - 3004
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-5°C;
参考文献
Primas, Nicolas; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain
Tetrahedron, 2009 , vol. 65, # 32 p. 6348 - 6353
