4-甲氧基-2-巯基苯甲酸合成路线 （共 6 条）
反应条件
potassium hydroxide in methanol
T=60°C;
参考文献
Khan, Safraz; Bernad, Pablo L.; Korshun, Vladimir A.; Southern, Edwin M.; Shchepinov, Mikhail S.
Synlett, 2005 , # 16 art. no. D18705ST, p. 2453 - 2456
反应条件
1: 83 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / 72 h / 20 °C
2: 70 percent / 14 h / 210 °C
3: 89 percent / aq. NaOH / 24 h / Heating
View Scheme
参考文献
Sugiyama, Hideyuki; Yoshida, Masato; Mori, Kouji; Kawamoto, Tomohiro; Sogabe, Satoshi; Takagi, Terufumi; Oki, Hideyuki; Tanaka, Toshimasa; Kimura, Hiroyuki; Ikeura, Yoshinori
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 613 - 624
反应条件
1: SOCl2 / Heating
2: 83 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / 72 h / 20 °C
3: 70 percent / 14 h / 210 °C
4: 89 percent / aq. NaOH / 24 h / Heating
View Scheme
参考文献
Sugiyama, Hideyuki; Yoshida, Masato; Mori, Kouji; Kawamoto, Tomohiro; Sogabe, Satoshi; Takagi, Terufumi; Oki, Hideyuki; Tanaka, Toshimasa; Kimura, Hiroyuki; Ikeura, Yoshinori
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 613 - 624
参考文献
Schenley Ind.
Patent: US2767173 , 1953 ;
反应条件
1: 25.3 g / K2CO3, KI, Cu bronze / dimethylformamide / 18 h / Heating
2: 5.0 g / conc. H2SO4 / 90 h / Heating
3: HI, acetic acid / 2 h / Heating
4: 1.0 g / pyridine / 16 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: 25.3 g / K2CO3, KI, Cu bronze / dimethylformamide / 18 h / Heating
2: 5.0 g / conc. H2SO4 / 90 h / Heating
3: 300 mg / 18 h / Heating
4: 48percent HI / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
