4-羟基-6-(3-吡啶)-2H-吡喃-2-酮合成路线 （共 10 条）
反应条件
T=25 - 150°C; P=3 Torr; 0.75 h;
参考文献
Narasimhan; Ammanamanchi
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 3945 - 3947
反应条件
1: 86 percent / potassium hydroxide / ethanol / 0.5 h / 20 °C
2: 96 percent / TFA / various solvent(s) / 2 h / 0 °C
View Scheme
参考文献
Schmidt, Dietmar; Conrad, Juergen; Klaiber, Iris; Beifuss, Uwe
Chemical Communications, 2006 , # 45 p. 4732 - 4734
反应条件
1: 88 percent / LDA, TMEDA / diethyl ether / 1.) 0 deg C, 3 h, 2.) room temperature, 30 h
2: 79 percent / 0.5 h / 150 °C / 3 Torr
View Scheme
参考文献
Hua, Duy H.; Chen, Yi; Sin, Hong-Sig; Maroto, Maria J.; Robinson, Paul D.; Newell, Steven W.; Perchellet, Elisabeth M.; Ladesich, James B.; Freeman, Jonathan A.; Perchellet, Jean-Pierre; Chiang, Peter K.
Journal of Organic Chemistry, 1997 , vol. 62, # 20 p. 6888 - 6896
反应条件
acetic acid in water; ethyl acetate
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1: dimethylformamide / 1 h / Ambient temperature
2: 87 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
3: 1.) LDA, 2.) p-toluenesulfonic acid / 1.) THF, -78 deg C, 15 min, 2.) THF, RT, 2 h
4: 39.7 percent / acetic acid / H2O; ethyl acetate
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1: 1.) LDA, 2.) p-toluenesulfonic acid / 1.) THF, -78 deg C, 15 min, 2.) THF, RT, 2 h
2: 39.7 percent / acetic acid / H2O; ethyl acetate
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1: 87 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
2: 1.) LDA, 2.) p-toluenesulfonic acid / 1.) THF, -78 deg C, 15 min, 2.) THF, RT, 2 h
3: 39.7 percent / acetic acid / H2O; ethyl acetate
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
aluminium trichloride
参考文献
Ziegler; Noelken
Monatshefte fuer Chemie, 1958 , vol. 89, p. 391
反应条件
1: 250 °C
2: AlCl3
View Scheme
参考文献
Ziegler; Noelken
Monatshefte fuer Chemie, 1958 , vol. 89, p. 391
反应条件
in diethyl ether
2 h; Ambient temperature;
参考文献
Narasimhan; Ammanamanchi
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 3945 - 3947
