3-羟基哌啶-1-羧酸甲酯合成路线 （共 9 条）
反应条件
TEA in dichloromethane T=0 - 20°C;
参考文献
Organic Letters, , vol. 7, # 20 p. 4309 - 4312
反应条件
hydrogen; platinum(IV) oxide in ethanol P=2250.2 Torr;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 35, # 4 p. 289 - 294
反应条件
potassium carbonate in water 20 h; Ambient temperature;
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 1 p. 69 - 77
反应条件
sodium tetrahydroborate; dihydrogen peroxide 1.) THF, room temperature, 7-8 h, 2.) 3N NaOH; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 104, # 24 p. 6697 - 6703
反应条件
1: anodic oxidation in tetraethylammonium p-toluenesulfonate 2: 96 percent / NH4Cl / 2 h / 20 - 100 Torr / Heating 3: 1.) sodium borohydride-boron trifluoride etherate, 2.) H2O2 / 1.) THF, room temperature, 7-8 h, 2.) 3N NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 24 p. 6697 - 6703
反应条件
1: 96 percent / NH4Cl / 2 h / 20 - 100 Torr / Heating 2: 1.) sodium borohydride-boron trifluoride etherate, 2.) H2O2 / 1.) THF, room temperature, 7-8 h, 2.) 3N NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 24 p. 6697 - 6703
反应条件
1: 70 percent / K2CO3 / xylene / 20 h / Heating
2: 90 percent / KOH / methanol; H2O / 72 h / Heating
View Scheme
参考文献
Falch; Krogsgaard-Larsen
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 1 p. 69 - 77
反应条件
1: 3-hydroxypiperidine-1-carboxylic acid methyl ester With methanol; tetraethylammonium p-toluenesulfonate
T=15°C; 8 h; Electrolysis;
2: thiophenol With toluene-4-sulfonic acid in dichloromethane
T=0°C; 2 h;
参考文献
Bartels, Marc; Zapico, Julian; Gallagher, Timothy
Synlett, 2004 , # 14 p. 2636 - 2638
反应条件
oxalyl dichloride; TEA; dimethyl sulfoxide in dichloromethane
T=20°C; Swern oxidation; 2 h;
参考文献
Smith, Nicole D.; Hayashida, Joji; Rawal, Viresh H.
Organic Letters, 2005 , vol. 7, # 20 p. 4309 - 4312
