2-氨基-5-苯基噻唑-4-羧酸甲酯合成路线 （共 9 条）
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=20 - 60°C; 3 h;
参考文献
Ladouceur, Gaetan H.; Schoen, William R.; Burke, Michael J.
Patent: US2003/195352 A1, 2003 ;
Location in patent: Page/Page column 35-36 ;
反应条件
sodium hydroxide in tert.-butylnitrite; acetonitrile
参考文献
Ladouceur, Gaetan H.; Bullock, William H.; Magnuson, Steven R.; O'Connor, Stephen J.; Smith, Roger A.; Shen, Quanrong; Liu, Qingjie; Su, Ning; Velthuisen, Emil J.; Campbell, Ann-Marie; Ehrlich, Paul P.
Patent: US2003/78258 A1, 2003 ;
反应条件
sodium bromide; sulfuric acid; sodium nitrite
参考文献
Hoffmann-La Roche Inc.
Patent: US5011849 A1, 1991 ;
US 5011849 A
反应条件
1: NaNO2; H3PO2 2: aq. LiOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3732 - 3736
反应条件
1: dichloroacetic acid methyl ester; benzaldehyde With sodium methylate in methanol; diethyl ether
T=0°C; 1 h;
2: thiourea in methanol
18 h; Heating / reflux;
参考文献
Ladouceur, Gaetan H.; Schoen, William R.; Burke, Michael J.
Patent: US2003/195352 A1, 2003 ;
Location in patent: Page/Page column 30; 34 ;
反应条件
1: methyl phenylpyruvate With pyridinium tribromide in dichloromethane; acetic acid
T=0°C; 1.5 h;
2: thiourea in ethanol
1 h; Heating / reflux;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.,
Patent: WO2004/67521 A1, 2004 ;
Location in patent: Page 108-109 ;
反应条件
1: methanol / 1) 60 deg C; 2) 20 deg C, 2 h
2: aq. Na2CO3
View Scheme
参考文献
Mamedov, B. A.; Nuretdinov, I. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 12 p. 2652 - 2653
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 12 p. 2856 - 2857
反应条件
1: benzaldehyde; dichloroacetic acid ethyl ester With sodium methylate in diethyl ether
2: methanol; thiourea Heating;
参考文献
Cui, Yong-Mei; Huang, Qing-Qing; Xu, Jie; Chen, Ling-Ling; Li, Jing-Ya; Ye, Qi-Zhuang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3732 - 3736
反应条件
sodium carbonate
Yield given;
参考文献
Mamedov, B. A.; Nuretdinov, I. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 12 p. 2652 - 2653
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 12 p. 2856 - 2857
