(S)-(+)-3-羟基异丁酸甲酯合成路线 （共 17 条）
反应条件
diisopropyl{1-[(S)-3,5-dioxa-4-phospha-cyclohepta(2,1-a;3,4-a')dinaphthalen-4-yl]-3-methyl-2-indolyl}phosphine; bis(norbornadiene)rhodium(I) tetrafluoroborate; hydrogen in dichloromethane T=-40°C; P=15001.5 Torr; 15 h; Inert atmosphere; Reactivity; PressureTemperatureConcentration; optical yield given as percent eeenantioselective reaction;
参考文献
Wassenaar, Jeroen; Kuil, Mark; Reek, Joost N. H.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1610 - 1614
反应条件
hydrogen; [(R,R)-Me-DuPhosRhCOD] triflate in methanol T=30°C; P=3000.3 Torr; Product distribution; Further Variations:Catalysts;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 185 - 189
反应条件
potassium carbonate in methanol T=5 - 10°C; 1 h;
参考文献
Czeskis, Boris A.; Moissenkov, Alexander M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1353 - 1354
反应条件
[Rh(dppb)(COD)]BF4; hydrogen in methanol T=20°C; P=45004.5 Torr; 20 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 16 p. 2533 - 2543
参考文献
Tetrahedron Letters, , vol. 22, # 37 p. 3555 - 3556
反应条件
in diethyl ether Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 47, # 12 p. 2400 - 2404
参考文献
Chemistry Letters, , # 8 p. 741 - 742
反应条件
nitrogen; diisobutylaluminium hydride in tetrahydrofuran; water; N,N-dimethyl-formamide; toluene
参考文献
Merck and Co., Inc.
Patent: US5155228 A1, 1992 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 0 deg C, 1 h, RT.;
参考文献
Parry, Ronald J.; Mizusawa, A.E.; Chiu, I.C.; Naidu, M.V.; Ricciardone, M.
Journal of the American Chemical Society, 1985 , vol. 107, # 8 p. 2512 - 2521
反应条件
anhydrous sodium hydrogen carbonate in tetrahydrofuran
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5506267 A1, 1996 ;
