(S)-(+)-3-羟基异丁酸甲酯合成路线 （共 17 条）
反应条件
camphor-10-sulfonic acid in dichloromethane
参考文献
Journal of the American Chemical Society, , vol. 132, p. 2157 - 2159
反应条件
pyridine; carbon tetrabromide; triphenylphosphine in tetrahydrofuran 1.) from 5 deg C to 10 deg C, 1 h, 2.) 25 deg C, 2 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 26, # 2.2 p. 364 - 369
Zhurnal Organicheskoi Khimii, , vol. 26, # 2 p. 425 - 432
反应条件
1: in diethyl ether
T=10 - 25°C;
2: With hydrogenchloride in diethyl ether; water
T=10 - 25°C; pH=4;
参考文献
AZAD PHARMACEUTICAL INGREDIENTS AG; UNIVERSITAeT ZUeRICH; BADER, Thomas; STUTZ, Alfred; BICHSEL, Hans-Ulrich; FU, Changchun
Patent: WO2010/9879 A2, 2010 ;
Location in patent: Page/Page column 96 ;
反应条件
1: in tetrahydrofuran; diethyl ether
T=0 - 20°C; 2 h;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
T=0°C;
参考文献
Formosa Laboratories, Inc.
Patent: US7491712 B1, 2009 ;
Location in patent: Page/Page column 15; Sheet 2/2 ;
反应条件
in diethyl ether
T=0°C; 1 h;
参考文献
Wilson, Stephen R.; Jacob, Linda
Journal of Organic Chemistry, 1992 , vol. 57, # 16 p. 4380 - 4385
反应条件
Yield given. Multistep reaction;
参考文献
Baker, Raymond; Boyes, R. Hugh O.; Broom, D. Mark P.; O'Mahony, Mary J.; Swain, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1613 - 1622
反应条件
N-bromosuccinmide; triphenylphosphine
参考文献
Nakamura, Eiichi; Sekiya, Kouichi; Kuwajima, Isao
Tetrahedron Letters, 1987 , vol. 28, # 3 p. 337 - 340
