(S)-(+)-2-氨基-1-己醇合成路线 （共 11 条）
反应条件
1: 89 percent / EDC; HOBT; N-methylmorpholine 2: 78 percent / DMSO; (COCl)2 / CH2Cl2 / -65 °C View Scheme
参考文献
Tavares, Francis X.; Deaton, David N.; Miller, Aaron B.; Miller, Larry R.; Wright, Lois L.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3891 - 3895
参考文献
Hunt, Thomas; Atherton-Watson, Hazel C.; Collingwood, Stephen P.; Coote, Kevin J.; Czarnecki, Sarah; Danahay, Henry; Howsham, Catherine; Hunt, Peter; Paisley, Derek; Young, Alice
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2877 - 2879
参考文献
Hunt, Thomas; Atherton-Watson, Hazel C.; Collingwood, Stephen P.; Coote, Kevin J.; Czarnecki, Sarah; Danahay, Henry; Howsham, Catherine; Hunt, Peter; Paisley, Derek; Young, Alice
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2877 - 2879
反应条件
hydrogen; palladium on activated charcoal in methanol
P=112509 Torr; 72 h;
参考文献
Segat-Dioury, Fabienne; Lingibe, Olivier; Graffe, Bernadette; Sacquet, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2000 , vol. 56, # 2 p. 233 - 248
反应条件
1: borane-tetrahydrofuran complex / acetonitrile / 3 h / 20 °C
2: 78 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr
View Scheme
参考文献
Segat-Dioury, Fabienne; Lingibe, Olivier; Graffe, Bernadette; Sacquet, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2000 , vol. 56, # 2 p. 233 - 248
反应条件
1: hydrobromic acid; acetic acid
2: potassium carbonate
3: borane-tetrahydrofuran complex / acetonitrile / 3 h / 20 °C
4: 78 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr
View Scheme
参考文献
Segat-Dioury, Fabienne; Lingibe, Olivier; Graffe, Bernadette; Sacquet, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2000 , vol. 56, # 2 p. 233 - 248
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile
T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 59 ;
反应条件
Yield given. Multistep reaction;
参考文献
Rinaldi, Peter L.; Wilk, Melody
Journal of Organic Chemistry, 1983 , vol. 48, # 13 p. 2141 - 2146
反应条件
1: 88 percent / dimethylformamide / 15 h / 20 °C
2: hydrobromic acid; acetic acid
3: potassium carbonate
4: borane-tetrahydrofuran complex / acetonitrile / 3 h / 20 °C
5: 78 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr
View Scheme
参考文献
Segat-Dioury, Fabienne; Lingibe, Olivier; Graffe, Bernadette; Sacquet, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2000 , vol. 56, # 2 p. 233 - 248
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
12 h; Heating;
参考文献
Takahata, Hiroki; Takehara, Hiroyuki; Ohkubo, Naoki; Momose, Takefumi
Tetrahedron: Asymmetry, 1990 , vol. 1, # 8 p. 561 - 566
