4-溴甲基-5-甲基-1,3-间二氧杂环戊烯-2-酮合成路线 （共 17 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane T=77°C; 6 h;
参考文献
S.I.M.S. S.r.l. - SOCIETA ITALIANA MEDICINALI SCANDICCI
Patent: WO2008/12852 A1, 2008 ;
Location in patent: Page/Page column 23; 36 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Boykin, David W.; Rahmathullah, M. Syed; Tidwell, Richard R.; Hall, James E.
Patent: US2002/19437 A1, 2002 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
University of Pittsburgh
Patent: US2002/193596 A1, 2002 ;
反应条件
2,2'-azo-bisisobutyronitrile in benzene T=20°C; 0.5 h; Heating / reflux;
参考文献
EP1445249 A1, ;
Page 116 ;
反应条件
sodium bromide in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
WO2009/93268 A1, ;
Page/Page column 16 ;
反应条件
silver nitrate; acetic acid in acetonitrile
参考文献
Farmitalia Carlo Erba S r l
Patent: US5416208 A1, 1995 ;
反应条件
1: 80 percent / Et3N / acetonitrile / 1 h / Ambient temperature 2: conc. HCl / methanol / 2 h / Ambient temperature View Scheme
参考文献
Alpegiani; Zarini; Perrone
Synthetic Communications, 1992 , vol. 22, # 9 p. 1277 - 1282
反应条件
1: 1.) potassium bicarbonate / 1.) DMF, 0 deg C, 3 h; 2.) 0 deg C, 3 h 2: 60 percent / 1N HCl / acetonitrile / 0.5 h / 0 - 5 °C / pH=2.0 View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 6 p. 2241 - 2248
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide 5 h; Ambient temperature;
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=30°C; 2 h; various periods of time (3 h); activation energy 29.1 kJ mol-1; Product distributionRate constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 67, # 5 p. 1419 - 1426
