NH4HCO3; triethylamine in dichloromethane T=7 - 10°C; 0.833333 h;

1: 80.8 percent / sodium bicarbonate, α,α'-azobisisobutyronitrile, Br2 / CCl4 / 1.08 h / 70 °C 2: 1.) potassium bicarbonate / 1.) DMF, 0 deg C, 3 h; 2.) 0 deg C, 3 h 3: 60 percent / 1N HCl / acetonitrile / 0.5 h / 0 - 5 °C / pH=2.0 View Scheme

1: 1.) potassium bicarbonate / 1.) DMF, 0 deg C, 3 h; 2.) 0 deg C, 3 h 2: 60 percent / 1N HCl / acetonitrile / 0.5 h / 0 - 5 °C / pH=2.0 View Scheme