1-苯基-3-丁烯-1-醇合成路线 （共 285 条）
反应条件
1.1: n-BuLi; t-BuOK / tetrahydrofuran; hexane / 0.75 h / -80 °C
1.2: 50 percent / tetrahydrofuran; hexane / 0.08 h / -80 °C
2.1: n-BuLi; t-BuOK / tetrahydrofuran; hexane / 0.75 h / -80 °C
2.2: 90 percent / tetrahydrofuran; hexane / 0.08 h / -80 °C
3.1: 100 percent / aq. H2O2; V2O5 / 2-methyl-propan-2-ol / 0.17 h / 20 °C
4.1: 85 percent / aq. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 12 h / 20 °C
View Scheme
参考文献
Angelaud, Remy; Landais, Yannick
Tetrahedron, 2000 , vol. 56, # 14 p. 2025 - 2036
反应条件
1.1: n-BuLi; t-BuOK / tetrahydrofuran; hexane / 0.75 h / -80 °C
1.2: 90 percent / tetrahydrofuran; hexane / 0.08 h / -80 °C
2.1: 100 percent / aq. H2O2; V2O5 / 2-methyl-propan-2-ol / 0.17 h / 20 °C
3.1: 85 percent / aq. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 12 h / 20 °C
View Scheme
参考文献
Angelaud, Remy; Landais, Yannick
Tetrahedron, 2000 , vol. 56, # 14 p. 2025 - 2036
反应条件
1: 100 percent / aq. H2O2; V2O5 / 2-methyl-propan-2-ol / 0.17 h / 20 °C
2: 85 percent / aq. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 12 h / 20 °C
View Scheme
参考文献
Angelaud, Remy; Landais, Yannick
Tetrahedron, 2000 , vol. 56, # 14 p. 2025 - 2036
反应条件
1: 75 percent / Sc(OTf)3 / CH2Cl2 / from -20 degC to room t.
2: 95 percent / TBAF / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Bonini, Bianca Flavia; Comes-Franchini, Mauro; Fochi, Mariafrancesca; Mazzanti, Germana; Nanni, Cristiano; Ricci, Alfredo
Tetrahedron Letters, 1998 , vol. 39, # 37 p. 6737 - 6740
反应条件
1: sec-BuLi / tetrahydrofuran / 1 h / -78 °C
2: 86 percent / tetrahydrofuran / 1 h / -78 °C
3: 91 percent / DIBAL / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Barner, Bruce A.; Mani, R.S.
Tetrahedron Letters, 1989 , vol. 30, # 40 p. 5413 - 5416
反应条件
1: 92 percent / CH2Cl2
2: sec-BuLi / tetrahydrofuran / 1 h / -78 °C
3: 86 percent / tetrahydrofuran / 1 h / -78 °C
4: 91 percent / DIBAL / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Barner, Bruce A.; Mani, R.S.
Tetrahedron Letters, 1989 , vol. 30, # 40 p. 5413 - 5416
反应条件
in toluene
addn. of benzaldehyde to tin-compd. at -20°C, after 1 h dilution of mixt. with hexane, pptn.; filtration, washing (hexane), evapn. of filtrate, chromy. (SiO2, hexane/ethylacetate 93:7);
参考文献
Auge, Jacques; Bourleaux, Guy
Journal of Organometallic Chemistry, 1989 , vol. 377, p. 205 - 210
反应条件
1: hydrogenchloride; water / methanol / 0.5 h / 20 °C
2: dipyridinium dichromate / dichloromethane / 14 h / 20 °C / Molecular sieve
3: potassium hydroxide / methanol; water / 14 h / 20 °C
View Scheme
参考文献
Ito, Suguru; Hayashi, Akira; Komai, Hirotomo; Yamaguchi, Hitoshi; Kubota, Yoshihiro; Asami, Masatoshi
Tetrahedron, 2011 , vol. 67, # 11 p. 2081 - 2089
反应条件
1: Al-MCM-41 (Si/Al = 48) / dichloromethane / 2 h / 30 °C / Inert atmosphere
2: hydrogenchloride; water / methanol / 0.5 h / 20 °C
3: dipyridinium dichromate / dichloromethane / 14 h / 20 °C / Molecular sieve
4: potassium hydroxide / methanol; water / 14 h / 20 °C
View Scheme
参考文献
Ito, Suguru; Hayashi, Akira; Komai, Hirotomo; Yamaguchi, Hitoshi; Kubota, Yoshihiro; Asami, Masatoshi
Tetrahedron, 2011 , vol. 67, # 11 p. 2081 - 2089
反应条件
1: dipyridinium dichromate / dichloromethane / 14 h / 20 °C / Molecular sieve
2: potassium hydroxide / methanol; water / 14 h / 20 °C
View Scheme
参考文献
Ito, Suguru; Hayashi, Akira; Komai, Hirotomo; Yamaguchi, Hitoshi; Kubota, Yoshihiro; Asami, Masatoshi
Tetrahedron, 2011 , vol. 67, # 11 p. 2081 - 2089
