乙基二氟(4-氟苯氧基)乙酸酯合成路线 （共 2 条）
反应条件
1: 4-Fluorophenyl alcohol With sodium hydride in N,N-dimethyl-formamide
0.25 h;
2: bromo-difluoroacetic acid,ethyl ester in N,N-dimethyl-formamide
T=0 - 90°C; 20 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2006/60494 A1, 2006 ;
Location in patent: Page/Page column 52 ;
WO 2006/060494 A1
反应条件
1: 4-Fluorophenyl alcohol With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.666667 h;
2: bromo-difluoroacetic acid,ethyl ester in N,N-dimethyl-formamide
3 h;
参考文献
VIROBAY, INC.; HART, Barry; GREEN, Michael; SETTI, Eduardo; ROEPEL, Michael
Patent: WO2010/56877 A2, 2010 ;
Location in patent: Page/Page column 34-35 ;
WO 2010/056877 A2
