4-(1,2,2-三甲基环戊基)-3-环己烯-1-酮合成路线 （共 16 条）
反应条件
1: hydrogen / Pd/C / ethanol / 3 h / 20 °C
2: 95 mg / BF3*OEt2 / benzene / 12 h / 0 - 20 °C
3: Raney nickel / ethanol / 2 h / Heating
4: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
5: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
sulfuric acid in tetrahydrofuran; water
T=20°C; 0.833333 h;
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1.1: 85 percent / lithium / tetrahydrofuran / 1 h / sonication
2.1: 97 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 3 h / 20 °C
3.1: magnesium / tetrahydrofuran
3.2: 70 percent / tetrahydrofuran / 4 h / 20 °C
4.1: 83 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 30 h / 20 °C
5.1: 70 percent / sodium borohydride / methanol / 2 h / cooling
6.1: 47 percent / propionic acid / 48 h / 180 °C
7.1: 98 percent / PhCH=RhCl2(PCy3)2 / CH2Cl2 / 4 h / 20 °C
8.1: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr
9.1: 84 mg / LiAlH4 / diethyl ether / 0.75 h / 0 - 20 °C
10.1: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
11.1: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
12.1: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
13.1: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1.1: magnesium / tetrahydrofuran
1.2: 70 percent / tetrahydrofuran / 4 h / 20 °C
2.1: 83 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 30 h / 20 °C
3.1: 70 percent / sodium borohydride / methanol / 2 h / cooling
4.1: 47 percent / propionic acid / 48 h / 180 °C
5.1: 98 percent / PhCH=RhCl2(PCy3)2 / CH2Cl2 / 4 h / 20 °C
6.1: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr
7.1: 84 mg / LiAlH4 / diethyl ether / 0.75 h / 0 - 20 °C
8.1: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
9.1: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
10.1: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
11.1: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1.1: 97 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 3 h / 20 °C
2.1: magnesium / tetrahydrofuran
2.2: 70 percent / tetrahydrofuran / 4 h / 20 °C
3.1: 83 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 30 h / 20 °C
4.1: 70 percent / sodium borohydride / methanol / 2 h / cooling
5.1: 47 percent / propionic acid / 48 h / 180 °C
6.1: 98 percent / PhCH=RhCl2(PCy3)2 / CH2Cl2 / 4 h / 20 °C
7.1: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr
8.1: 84 mg / LiAlH4 / diethyl ether / 0.75 h / 0 - 20 °C
9.1: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
10.1: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
11.1: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
12.1: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1: 70 percent / sodium borohydride / methanol / 2 h / cooling
2: 47 percent / propionic acid / 48 h / 180 °C
3: 98 percent / PhCH=RhCl2(PCy3)2 / CH2Cl2 / 4 h / 20 °C
4: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr
5: 84 mg / LiAlH4 / diethyl ether / 0.75 h / 0 - 20 °C
6: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
7: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
8: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
9: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1: 83 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 30 h / 20 °C
2: 70 percent / sodium borohydride / methanol / 2 h / cooling
3: 47 percent / propionic acid / 48 h / 180 °C
4: 98 percent / PhCH=RhCl2(PCy3)2 / CH2Cl2 / 4 h / 20 °C
5: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr
6: 84 mg / LiAlH4 / diethyl ether / 0.75 h / 0 - 20 °C
7: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
8: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
9: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
10: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1: 47 percent / propionic acid / 48 h / 180 °C
2: 98 percent / PhCH=RhCl2(PCy3)2 / CH2Cl2 / 4 h / 20 °C
3: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr
4: 84 mg / LiAlH4 / diethyl ether / 0.75 h / 0 - 20 °C
5: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
6: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
7: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
8: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
2: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
3: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
反应条件
1: pyridinium chlorochromate; silica gel / CH2Cl2 / 0.5 h / 20 °C
2: 14 mg / (PPh3)3RhCl / benzene / 48 h / 120 - 130 °C
3: lithium; liq. ammonia / ethanol; tetrahydrofuran / 2.5 h
4: 147 mg / sulphuric acid / tetrahydrofuran; H2O / 0.83 h / 20 °C
View Scheme
参考文献
Srikrishna; Satyanarayana
Synthetic Communications, 2004 , vol. 34, # 21 p. 3847 - 3864
