4-甲氧基-2,3,6-三甲基苯磺酰氯合成路线 （共 4 条）
反应条件
chlorosulfonic acid in dichloromethane T=-10 - -5°C;
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 0 °C 1.2: 92 percent / tetrahydrofuran / 3 h / 0 °C 2.1: chlorosulfonic acid / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 8 p. 1337 - 1340
反应条件
1: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate 2: 1.) 0.2 N H2SO4, 2.) hydrogen / 2.) palladium black / 1.) ethyl acetate, 2.) methanol View Scheme
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
反应条件
sodium hydroxide 1.) acetone, 3 h, 2.) ethyl acetate; Yield given. Multistep reaction;
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
