Z-Arg(Mtr)-OH 环己铵盐合成路线 (共 4 条)
反应条件
1: 72.5 percent / chlorosulfonic acid / CH2Cl2 / -10 - -5 °C 2: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 10 p. 2825 - 2831
反应条件
1: 99.8 percent / 60percent NaH in oil / dimethylsulfoxide / 10 h / Ambient temperature 2: 72.5 percent / chlorosulfonic acid / CH2Cl2 / -10 - -5 °C 3: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 10 p. 2825 - 2831
反应条件
sodium hydroxide 1.) acetone, 3 h, 2.) ethyl acetate; Yield given. Multistep reaction;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 10 p. 2825 - 2831
反应条件
sulfuric acid; hydrogen; palladium 1.) ethyl acetate, 2.) methanol; Yield given. Multistep reaction;
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831