2-甲基-2-丙基4-(3-氰基苯基)-1-哌嗪羧酸酯合成路线 （共 3 条）
反应条件
1: With Amberlyst(R) 15 in dichloromethane T=20°C; 2: With ammonium hydroxide in methanol T=20°C; 1.5 h;
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
反应条件
1: With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate in xylene
T=50°C;
2: With macroporous polymer-supported isocyanate in xylene
T=50°C; 24 h;
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1953148 A1, 2008 ;
Location in patent: Page/Page column 162-163 ;
EP 1953148 A1
