1-(3,5-二溴噻吩-2-基)乙酮合成路线 （共 3 条）
反应条件
1: 2,3,5-tribromothiophene With n-butyllithium in diethyl ether
T=-78°C; 0.5 h;
2: N-methoxy N-methylactamide T=-78 - 25°C; 0.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/85227 A1, 2005 ;
Location in patent: Page/Page column 50; 125 ;
WO 2005/085227 A1
反应条件
aluminium trichloride in carbon disulfide
1) RT, overnight, 2) reflux, 1 h;
参考文献
Agua, M. J. del; Alvarez-Insua, A. S.; Conde, S.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1345 - 1347
反应条件
aluminium trichloride in carbon disulfide
1) RT, overnight, 2) reflux, 1 h; Product distributionMechanism;
参考文献
Agua, M. J. del; Alvarez-Insua, A. S.; Conde, S.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1345 - 1347
