1-碘-2-(甲氧基甲氧基)苯合成路线 （共 19 条）
反应条件
1: 50 percent / PdCl2(PPh3)2 / CHCl3 / 80 °C / 3800 Torr 2: 65 percent / 3 N HCl / 1 h / Heating View Scheme
参考文献
Sakamoto; Yasuhara; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1137 - 1139
反应条件
1: CuI, Et3N / PdCl2(PPh3)2 / 2 h / Ambient temperature 2: 1.) p-toluenesulfonic acid, (COOH)2*2H2O / 1.) H2O, C6H6, rt., 12 h; 2.) 50percent aq. MeOH, reflux, 2 h View Scheme
参考文献
Kondo, Yoshinori; Shiga, Futoshi; Murata, Naoko; Sakamoto, Takao; Yamanaka, Hiroshi
Tetrahedron, 1994 , vol. 50, # 41 p. 11803 - 11812
反应条件
1: 1) 1.4M sec-BuLi in hexane, 2) ZnBr2, 3) Pd(PPh3)4 / 1) THF, 1 h, -78 deg C, 2) THF, hexane, -78 deg C, 15 min then -78 deg C to RT, 3) THF, hexane, 48 h, RT 2: 2N HCl / methanol / Heating View Scheme
参考文献
Superchi, Stefano; Sotomayor, Nuria; Miao, Guobin; Joseph, Babu; Snieckus, Victor
Tetrahedron Letters, 1996 , vol. 37, # 34 p. 6057 - 6060
反应条件
di-tert-butylphosphine; (2,6-iPr2-C6H3OCO-N)-imidazolium-(N-CH2C6H4-2-Br) bromide; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=95°C; Suzuki-Miyaura coupling; 72 h;
参考文献
Palencia, Hector; Garcia-Jimenez, Federico; Takacs, James M.
Tetrahedron Letters, 2004 , vol. 45, # 20 p. 3849 - 3853
反应条件
1: Et2NH / PdCl2(PPh3)2, CuI / 12 h / Ambient temperature 2: conc. HCl / methanol / 24 h / Ambient temperature View Scheme
参考文献
Okamoto, Ryuichi; Okazaki, Eri; Noguchi, Keiichi; Tanaka, Ken
Organic Letters, 2011 , vol. 13, # 18 p. 4894 - 4897
反应条件
1: 2-iodophenol With n-butyllithium in tetrahydrofuran
2: chloromethyl methyl ether
参考文献
Boyer, Alistair; Isono, Naohiro; Lackner, Sebastian; Lautens, Mark
Tetrahedron, 2010 , vol. 66, # 33 p. 6468 - 6482
反应条件
n-butyllithium; iodine
1.) ether, hexane, 2 h, r.t., 2.) 1 min, r.t.; Yield given. Multistep reaction;
参考文献
Townsend, Craig A.; Bloom, Leslie M.
Tetrahedron Letters, 1981 , vol. 22, # 40 p. 3923 - 3924
反应条件
sodium hydride
5 h; Ambient temperature;
参考文献
Yoneda, Eiji; Sugioka, Takashi; Hirao, Kojiro; Zhahg, Shi-Wei; Takahashi, Shigetoshi
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 477 - 483
反应条件
1: Et2NH / PdCl2(PPh3)2, CuI / 12 h / Ambient temperature
2: conc. HCl / methanol / 24 h / Ambient temperature
3: 45 percent / Et3N, H2O / Rh6(CO)16 / dioxane / 3 h / 175 °C / 76000 Torr
View Scheme
参考文献
Yoneda, Eiji; Sugioka, Takashi; Hirao, Kojiro; Zhahg, Shi-Wei; Takahashi, Shigetoshi
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 477 - 483
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 50 °C / |Inert atmosphere
2: hydrogenchloride / methanol; water / |Reflux; |Inert atmosphere
3: potassium carbonate / water / 2 h / 110 °C / |Microwave irradiation; |Inert atmosphere; |Green chemistry
View Scheme
参考文献
Sun, Shi-Xin; Wang, Jun-Jie; Xu, Zi-Jun; Cao, Lu-Ya; Shi, Zi-Fa; Zhang, Hao-Li
Tetrahedron, 2014 , vol. 70, # 24 p. 3798 - 3806
