1-碘-2-(甲氧基甲氧基)苯合成路线 （共 19 条）
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 50 °C / |Inert atmosphere
2: hydrogenchloride / methanol; water / |Reflux; |Inert atmosphere
3: potassium carbonate / water / 2 h / 110 °C / |Microwave irradiation; |Inert atmosphere; |Green chemistry
View Scheme
参考文献
Sun, Shi-Xin; Wang, Jun-Jie; Xu, Zi-Jun; Cao, Lu-Ya; Shi, Zi-Fa; Zhang, Hao-Li
Tetrahedron, 2014 , vol. 70, # 24 p. 3798 - 3806
反应条件
1: Et2NH / PdCl2(PPh3)2, CuI / 12 h / Ambient temperature
2: conc. HCl / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Yoneda, Eiji; Sugioka, Takashi; Hirao, Kojiro; Zhahg, Shi-Wei; Takahashi, Shigetoshi
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 477 - 483
反应条件
1: Et2NH / PdCl2(PPh3)2, CuI / 12 h / Ambient temperature
2: conc. HCl / methanol / 24 h / Ambient temperature
3: 23 percent / Et3N, H2O / Rh6(CO)16 / dioxane / 3 h / 175 °C / 76000 Torr
View Scheme
参考文献
Yoneda, Eiji; Sugioka, Takashi; Hirao, Kojiro; Zhahg, Shi-Wei; Takahashi, Shigetoshi
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 477 - 483
反应条件
1: 84 percent / PdCl2(PPh3)2; CuI; Et3N / 50 °C
2: 99 percent / aq. HCl / tetrahydrofuran; propan-2-ol / 20 °C
View Scheme
参考文献
Fuerstner, Alois; Davies, Paul W.
Journal of the American Chemical Society, 2005 , vol. 127, # 43 p. 15024 - 15025
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
T=50°C; 0.666667 h; Inert atmosphere;
参考文献
Boyer, Alistair; Isono, Naohiro; Lackner, Sebastian; Lautens, Mark
Tetrahedron, 2010 , vol. 66, # 33 p. 6468 - 6482
反应条件
1: 68 percent / Pd(PPh3)2Cl2 / dioxane / 4 h / Heating
2: 1) H2, 2) conc. HCl, AcOH / 1) Raney nickel W-1 / 1) MeOH, 5.6 atm, 2 h, 2) 80 deg C, 20 min
View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Uchiyama, Daishi; Yamanaka, Hiroshi
Tetrahedron, 1991 , vol. 47, # 28 p. 5111 - 5118
反应条件
1: 88 percent / triphenylphosphine; triethylamine; copper(I) iodide / bis(triphenylphosphine)palladium(II) chloride / 80 °C
2: 70 percent / sodium hydroxide / toluene / 3.5 h / Heating
View Scheme
参考文献
Liu, Jun; Liu, Yuanhong
Organic Letters, 2012 , vol. 14, # 18 p. 4742 - 4745,4
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 50 °C / |Inert atmosphere
2: hydrogenchloride / methanol; water / |Reflux; |Inert atmosphere
3: potassium carbonate / water / 2 h / 110 °C / |Microwave irradiation; |Inert atmosphere; |Green chemistry
View Scheme
参考文献
Sun, Shi-Xin; Wang, Jun-Jie; Xu, Zi-Jun; Cao, Lu-Ya; Shi, Zi-Fa; Zhang, Hao-Li
Tetrahedron, 2014 , vol. 70, # 24 p. 3798 - 3806
反应条件
1: 90 percent / PdCl2(PPh3)2; CuI; Et3N / 50 °C
2: 88 percent / aq. HCl / tetrahydrofuran; propan-2-ol / 20 °C
3: 98 percent / PtCl2 / toluene / 5 h / 80 °C
View Scheme
参考文献
Fuerstner, Alois; Davies, Paul W.
Journal of the American Chemical Society, 2005 , vol. 127, # 43 p. 15024 - 15025
