1H-吡咯并[2,3-B]吡啶-3-羧酸甲酯合成路线 （共 4 条）
反应条件
sulfuric acid in methanol T=20°C; 16 h; Heating / reflux;
参考文献
WO2004/111048 A1, ;
Page 40 ;
反应条件
triethylamine T=20°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/28475 A2, 2005 ;
Location in patent: Page/Page column 131-132 ;
WO 2005/028475 A2
反应条件
sodium t-butanolate in 1,4-dioxane T=80°C; 3 h; Inert atmosphere;
参考文献
Chaulet, Charlotte; Croix, Cecile; Basset, Joan; Pujol, Maria-Dolores; Viaud-Massuard, Marie-Claude
Synlett, 2010 , # 10 p. 1481 - 1484
反应条件
in methanol; hexane; toluene T=0 - 20°C; 1 h; Product distribution / selectivity;
参考文献
WO2008/5457 A2, ;
Page/Page column 78 ;
WO 2008/005457 A2
