4-(二氟亚甲基)-L-脯氨酸甲酯合成路线 （共 5 条）
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702
反应条件
1: 100 percent / aq. NaOH / tetrahydrofuran / 20 °C
2: trichloroisocyanuric acid; TEMPO / CH2Cl2
3: HMPT; Zn / tetrahydrofuran
4: TFA / CH2Cl2
View Scheme
参考文献
Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702
反应条件
1: trichloroisocyanuric acid; TEMPO / CH2Cl2
2: HMPT; Zn / tetrahydrofuran
3: TFA / CH2Cl2
View Scheme
参考文献
Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702
反应条件
1: HMPT; Zn / tetrahydrofuran
2: TFA / CH2Cl2
View Scheme
参考文献
Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702
反应条件
1: SOCl2
2: 100 percent / aq. NaOH / tetrahydrofuran / 20 °C
3: trichloroisocyanuric acid; TEMPO / CH2Cl2
4: HMPT; Zn / tetrahydrofuran
5: TFA / CH2Cl2
View Scheme
参考文献
Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702
