3,5-二甲基-4-碘苯酚合成路线 （共 14 条）
反应条件
potassium fluoride; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran
Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: EP1856090 B1, 2009 ;
Location in patent: Page/Page column 58 ;
反应条件
potassium hydroxide in dimethyl sulfoxide
T=25°C; 2 h;
参考文献
Moorthy, Jarugu Narasimha; Singhal, Nidhi; Senapati, Kalyan
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 80 - 84
参考文献
Goldschmidt; Suchanek
Chemische Berichte, 1957 , vol. 90, p. 19,25
反应条件
1.1: pyridine / 10 °C
1.2: 39 - 55 °C / Large scale reaction
2.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine
3.1: [Rh(1,5-COD)(S,S-Et-FerroTANE)]BF4; hydrogen / ethyl acetate / 16 h / 60 °C / 3750.38 Torr
4.1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 16 h / 20 °C
4.2: 5 h / 20 °C
4.3: pH 4
View Scheme
参考文献
Praquin, Celine F. B.; De Koning, Pieter D.; Peach, Philip J.; Howard, Roger M.; Spencer, Sarah L.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1124 - 1129
