8-(4-溴丁基)-8-氮杂螺[4.5]癸烷-7,9-二酮合成路线 （共 5 条）
反应条件
18-crown-6 ether; potassium carbonate in toluene T=111°C; 24 h; Inert atmosphere;
参考文献
Jaronczyk, Malgorzata; Wolosewicz, Karol; Gabrielsen, Mari; Nowak, Gabriel; Kufareva, Irina; Mazurek, Aleksander P.; Ravna, Aina W.; Abagyan, Ruben; Bojarski, Andrzej J.; Sylte, Ingebrigt; Chilmonczyk, Zdzislaw
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 200 - 210
参考文献
Mead Johnson and Company
Patent: US4320131 A1, 1982 ;
反应条件
potassium carbonate in acetonitrile T=60°C; 24 h;
参考文献
Tetrahedron, , vol. 59, # 20 p. 3665 - 3672
反应条件
potassium carbonate in acetonitrile 12 h; Heating;
参考文献
Yevich, J. P.; Temple, D. L.; New, J. S.; Taylor, Duncan P.; Riblet, L. A.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 194 - 203
反应条件
potassium iodide; potassium carbonate in chloroform; acetonitrile
参考文献
Mead Johnson and Company
Patent: US4411901 A1, 1983 ;
