2-(((3aR,4R,6R,6aR)-6-(6-氨基-9H-嘌呤-9-基)-2,2-二甲基四氢呋喃并[3,4-d][1,3]二氧代-4-基)甲基)异吲哚啉-1,3-二酮合成路线 (共 5 条)
反应条件
hydrazine hydrate in ethanol 2 h; Heating;
参考文献
Reeve, Anne M.; Townsend, Craig A.
Tetrahedron, 1998 , vol. 54, # 52 p. 15959 - 15974
反应条件
1: 77 percent / hydrazine hydrate / ethanol / Heating 2: 50percent aq. formic acid / 24 h / Ambient temperature View Scheme
参考文献
Kolb, Michael; Danzin, Charles; Barth, Jacqueline; Claverie, Nicole
Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 550 - 556
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
Inert atmosphere;
参考文献
Moukha-Chafiq, Omar; Reynolds, Robert C.
ACS Combinatorial Science, 2013 , vol. 15, # 3 p. 147 - 152
反应条件
1.1: toluene-4-sulfonic acid / water
1.2: 1 h
1.3: pH 8
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C
View Scheme
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
WO 2012/082436 A2
反应条件
1.1: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux
2.1: methanol / 0.5 h / 20 °C
2.2: 2 h
2.3: pH 8
View Scheme
参考文献
Moukha-Chafiq, Omar; Reynolds, Robert C.
ACS Combinatorial Science, 2013 , vol. 15, # 3 p. 147 - 152