diisobutylaluminium hydride in dichloromethane; toluene T=-78°C; Reduction;

Cl2Ni(1,2-bis(diphenylphosphino)ethane) in diethyl ether 16 h; Ambient temperature;

1: diisopropylethylamine; benzyltriethylammonium chloride; palladium(II) acetate / dimethylformamide / 6 h / 80 °C 2: 35 percent hydroperchloric acid / tetrahydrofuran / 48 h / Heating 3: 84 percent / diisobutylaluminum hydride / toluene; CH2Cl2 / -78 °C View Scheme