5-溴-2-甲氧基苯甲醇合成路线 （共 13 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran; water
参考文献
Sankyo Co., Ltd.
Patent: JP2005/120047 A, 2005 ;
Location in patent: Page/Page column 89-90 ;
反应条件
bis(collidine)bromine(I) hexafluorophosphate in dichloromethane T=20°C; 0.5 h;
参考文献
Rousseau; Robin
Tetrahedron Letters, 2000 , vol. 41, # 46 p. 8881 - 8885
反应条件
N-bromosuccinmide; water in 1,4-dioxane T=25 - 30°C; 1 h;
参考文献
Synthetic Communications, , vol. 37, # 9 p. 1571 - 1577
参考文献
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 205, p. 146
参考文献
Chemische Berichte, , vol. 42, p. 3499
反应条件
1: pyridine, thionyl chloride / toluene / 24 h / Ambient temperature 2: KI / dimethylsulfoxide / 20 h / Ambient temperature View Scheme
参考文献
Knorr; Hoerlein
Chemische Berichte, 1909 , vol. 42, p. 3499
反应条件
1: benzene; PCl5 2: diluted alcohol 3: alcoholic KOH-solution / 100 - 110 °C View Scheme
参考文献
Knorr; Hoerlein
Chemische Berichte, 1909 , vol. 42, p. 3499
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/80382 A1, 2007 ;
Location in patent: Page/Page column 131 ;
WO 2007/080382 A1
反应条件
phosphorus tribromide in dichloromethane T=0°C; 0.25 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 73 ;
US 20070249607 A1
反应条件
phosphorus pentachloride; benzene
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
