5-溴-2-甲氧基苯甲醇合成路线 （共 13 条）
反应条件
1: SOCl2 / CH2Cl2 / 2 h / 20 °C
2: 4.0 g / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1.1: (COBr)2; triphenyl-phosphine oxide / chloroform / 7 h
2.1: [2,2']bipyridinyl; copper(l) iodide / benzene / 5 - 20 °C
3.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
3.2: 0.5 h / 0 °C
View Scheme
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
反应条件
1.1: SOCl2 / CH2Cl2 / 2 h / 20 °C
2.1: 4.0 g / tetrahydrofuran / 18 h / 20 °C
3.1: Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; aq. K2CO3 / dimethylformamide / 80 °C
3.2: 42 percent / aq. HCl / dimethylformamide / 1 h
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
