(2S,3aS,7aS)-八氢吲哚-2-羧酸合成路线 （共 26 条）
反应条件
hydrogen; acetic acid; platinum on carbon T=20°C; P=3750.38 Torr;
参考文献
Dubuffet, Thierry; Langlois, Pascal
Patent: US2006/167273 A1, 2006 ;
Location in patent: Page/Page column 2 ;
反应条件
rhodium in 1,4-dioxane; methanol; water
参考文献
Adir Et Cie
Patent: US4914214 A1, 1990 ;
反应条件
1: With sodium hydroxide; water T=30 - 35°C; 5 h; 2: With hydrogenchloride in water pH=4.5 - 4.8;
参考文献
EP1792896 A1, ;
Page/Page column 7; 9 ;
反应条件
hydrogen; acetic acid; platinum(IV) oxide T=60°C; 24 h; atmospheric pressure;
参考文献
Sayago, Francisco J.; Pueyo, Maria J.; Calaza, M. Isabel; Jimenez, Ana I.; Cativiela, Carlos
Chirality, 2011 , vol. 23, # 7 p. 507 - 513
反应条件
hydrogenchloride in water 4 h; Heating;
参考文献
Blankley; Kaltenbronn; DeJohn; Werner; Bennett; Bobowski; Krolls; Johnson; Pearlman; Hoefle
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 992 - 998
反应条件
1: With methanol; sodium hydroxide; water 2 h; Heating / reflux; 2: With hydrogenchloride; water in methanol pH=6 - 7;
参考文献
US2007/32661 A1, ;
Page/Page column 4 ;
反应条件
1: H2 / Rh/C / acetic acid 2: aq. 15percent HCl / 4 h / Heating 3: 96.6 percent / 2N NaOH / H2O / 3 h / 5 °C 5: 87.8 percent / HCl / H2O / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 6 p. 992 - 998
反应条件
sodium hydroxide in ethanol; water T=25°C;
参考文献
Tetrahedron Letters, , vol. 23, # 16 p. 1677 - 1680
反应条件
1: hydrogen / Pd/C / ethanol 2: NaOH / H2O; ethanol / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 23, # 16 p. 1677 - 1680
反应条件
1: 96.6 percent / 2N NaOH / H2O / 3 h / 5 °C 3: 87.8 percent / HCl / H2O / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 6 p. 992 - 998
