3-溴-4-甲氧基-5-甲基苯甲酸合成路线 （共 5 条）
反应条件
bromine in 1,4-dioxane
T=20°C; 168 h;
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
反应条件
1.1: Mg / tetrahydrofuran; diethyl ether / 1.5 h / Heating
1.2: 82 percent / tetrahydrofuran; diethyl ether / 2 h / 20 °C
2.1: 84 percent / Br2 / dioxane / 168 h / 20 °C
View Scheme
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
参考文献
Zincke
Justus Liebigs Annalen der Chemie, 1913 , vol. 400, p. 33
反应条件
1: 72 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
2: 87 percent / MnO2 / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
反应条件
1: 72 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
2: 87 percent / MnO2 / CH2Cl2 / 12 h / 20 °C
3: aq. m-CPBA / CH2Cl2 / 12 h / 20 °C
4: 1.68 g / K2CO3 / methanol / 0.25 h / 20 °C
View Scheme
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
