2-溴苯并[D]噻唑-6-醇合成路线 （共 3 条）
反应条件
1: With boron tribromide in dichloromethane 2: With water in dichloromethane T=20°C; 2 h;
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; CAI, Lisheng; PIKE, Victor W.
Patent: WO2013/40183 A1, 2013 ;
Location in patent: Paragraph 0062 ;
反应条件
1.1: tert.-butylnitrite; copper(I) bromide / acetonitrile / 3 h 2.1: boron tribromide / dichloromethane 2.2: 2 h / 20 °C View Scheme
反应条件
1: With potassium carbonate in water; N,N-dimethyl-formamide
Suzuki-Miyaura Coupling; 1 h; Inert atmosphere;
2: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; N,N-dimethyl-formamide
T=60°C; Suzuki-Miyaura Coupling; 0.25 h; Inert atmosphereMicrowave irradiation; TemperatureTime;
参考文献
Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde
Tetrahedron, 2013 , vol. 69, # 35 p. 7345 - 7353
