N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲合成路线 （共 7 条）
反应条件
formic acid; palladium(II) hydroxide/carbon in tetrahydrofuran; water
T=60°C; 3 h;
参考文献
Lukin, Kirill A.; Hsu, Margaret Chi-Ping; Fernando, Dilinie P.; Kotecki, Brian J.; Leanna, Marvin R.
Patent: US2007/244178 A1, 2007 ;
Location in patent: Page/Page column 14 ;
反应条件
sodium hydroxide in methanol
T=20°C; 0.5 h;
参考文献
Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Surowy, Carol S.; Honore, Prisca; Marsh, Kennan C.; Hannick, Steven M.; McDonald, Heath A.; Wetter, Jill M.; Sullivan, James P.; Jarvis, Michael F.; Faltynek, Connie R.; Lee, Chih-Hung
Journal of Medicinal Chemistry, 2008 , vol. 51, # 3 p. 392 - 395
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / |Inert atmosphere
1.2: Friedel-Crafts Acylation / 1.5 h / 0 - 5 °C / |Inert atmosphere
2.1: ammonia
3.1: water; methanol / 1 h / 65 °C / |Large scale
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
反应条件
1: sulfuric acid / dichloromethane / 2 h / 90 °C / |Large scale
2: ammonia
3: water; methanol / 1 h / 65 °C / |Large scale
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
5: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
反应条件
1: ammonia
2: water; methanol / 1 h / 65 °C / |Large scale
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
4: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
反应条件
1: water; methanol / 1 h / 65 °C / |Large scale
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
3: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
反应条件
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
2: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
