1: With (R)-N-acetylleucine in methanol T=65°C; 1 h; 2: With sodium hydroxide

1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr 2: (R)-N-acetylleucine / methanol / 1 h / 65 °C View Scheme

1.1: AlCl3, aluminium chloride / dichloromethane / 0.25 h / 0 °C 1.2: 1.25 h / 0 °C 1.3: Cooling with ice 2.1: sulfuric acid / dichloromethane / 2 h / 90 °C 3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / Reflux 4.1: potassium tert-butylate / tetrahydrofuran / 20 °C 4.2: 0 - 20 °C 5.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr 6.1: (R)-N-acetylleucine / methanol / 1 h / 65 °C View Scheme

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / Reflux 2.1: potassium tert-butylate / tetrahydrofuran / 20 °C 2.2: 0 - 20 °C 3.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr 4.1: (R)-N-acetylleucine / methanol / 1 h / 65 °C View Scheme

1.1: sulfuric acid / dichloromethane / 2 h / 90 °C 2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / Reflux 3.1: potassium tert-butylate / tetrahydrofuran / 20 °C 3.2: 0 - 20 °C 4.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr 5.1: (R)-N-acetylleucine / methanol / 1 h / 65 °C View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C 1.2: 0 - 20 °C 2.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr 3.1: (R)-N-acetylleucine / methanol / 1 h / 65 °C View Scheme

5 palladium on charcoal; hydrogen in acetic acid T=10 - 40°C; Large scale;