反应条件
1.1: 78 percent / acetonitrile / 2 h / 20 °C
2.1: DCC; DMAP / CH2Cl2 / 12 h / 20 °C
3.1: 21 mg / Et3N / toluene / 0.5 h / Heating
4.1: 99 percent / H2 / Pd/C / methanol; ethyl acetate / 0.5 h / 20 °C
5.1: 96 percent / I2; PPh3; imidazole / CH2Cl2 / 2 h
6.1: t-BuLi / diethyl ether; pentane / 0.05 h / -78 °C
6.2: diethyl ether; pentane; tetrahydrofuran / 2.17 h / -78 - 20 °C
7.1: 433 mg / aq. K3PO4; PdCl2(dppf)*CH2Cl2 / diethyl ether; tetrahydrofuran; dimethylformamide / 18 h
8.1: DIBAL-H / toluene / 2 h / -78 °C
9.1: 361 mg / pyridine / 8 h / 20 °C
10.1: 91 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C
11.1: 42 percent / SnCl4; molecular sieves 4A / CHCl3; CH2Cl2 / 14 h / -5 - 20 °C
12.1: 87 percent / NaOMe / methanol / 15 h / 25 °C
13.1: 98 percent / Et3N / CH2Cl2
14.1: 62 percent / IBX / dimethylformamide / 36 h
15.1: 50 percent / aq. HF / acetonitrile / 20 °C
View Scheme
参考文献
Yuan, Yu; Men, Hongbin; Lee, Chulbom
Journal of the American Chemical Society, 2004 , vol. 126, # 45 p. 14720 - 14721
