1: With acetic acid; thiourea in ethanol
16 h; Heating / reflux;
2: With hydrogenchloride in ethanol
16 h; Heating / reflux;
3: With sodium carbonate in water; ethyl acetate
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/108676 A1, 2004 ;
Location in patent: Page 143 ;
WO 2004/108676 A1
1: (3-{2-[(chloroacetyl)amino]-2-methylpropyl}phenyl)acetic acid With acetic acid; thiourea in ethanol
5 h; Heating / reflux;
2: ethanol With sulfuric acid in water
T=20°C; 1 h;
参考文献
Brown, Alan Daniel; James, Kim; Lane, Charlotte Alice Louise; Moses, Ian Brian; Thomson, Nicholas Murray
Patent: US2005/171147 A1, 2005 ;
Location in patent: Page/Page column 25 ;
1: sulfuric acid; acetic acid / dichloromethane / 5 - 20 °C / Large scale reaction
2: sulfuric acid / 1.5 h / Reflux; Large scale reaction
3: acetic acid; thiourea / ethanol / 4 h / Reflux
View Scheme
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Morrison, Natalie A.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.; Yazbeck, Daniel R.
Organic Process Research and Development, 2011 , vol. 15, # 4 p. 871 - 875
De Koning, Pieter D.; Gladwell, Iain R.; Morrison, Natalie A.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.; Yazbeck, Daniel R.
Organic Process Research and Development, 2011 , vol. 15, # 4 p. 871 - 875
